Background/aims: The diagnosis of small cell lung carcinoma (SCLC) on bronchial biopsy is often problematical as a result of intense crush artefact. Several antibodies are now available to help in the diagnosis of SCLC and their value was assessed in this clinical situation.
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WhatsAppGet PriceGet A QuoteBackground The aim of this study was to analyze the frequency of Thyroid Transcription Factor (TTF)-1 expression in small cell lung cancer (SCLC) and its value for the diagnosis of SCLC, the response to first line treatment as well as the prognostic impact on overall survival (OS). Methods We analyzed a total of 294 patients (m, n = 184; f, n = 110) with SCLC (stage IIIA, n = 32; IIIB, n = 87
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WhatsAppGet PriceGet A QuoteThe lung is a site of platelet biogenesis and a reservoirthe lung is a site of platelet biogenesis and a reservoirMar 22 2017 d e frequencies d and cell counts e of lung haematopoietic progenitor populations n 3 f h cd45apc mab was injected intravenously via the tail vein 5 min before lung digestion and, design cell lung for crusher
WhatsAppGet PriceGet A QuoteSmall Cell Lung Cancer. In contrast to SCLC, which arises within submucosal tissues that hide the cells of origin, non-SCLC tumors appear to originate from surface epithelial cells that have undergone a gradual transition through the morphologic changes of squamous metaplasia and preneoplastic dysplasia.
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WhatsAppGet PriceGet A QuoteBackground Programmed cell death-1 (PD-1) immune checkpoint inhibitor antibody has proven to be effective in advanced non-small cell lung cancer (NSCLC) patients positive for programmed cell death-1 ligand-1 (PD-L1). However, there are currently no prospective studies evaluating PD-L1 expression for small biopsy samples. Methods To prospectively investigate the reliability of small samples for
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WhatsAppGet PriceGet A QuoteBackground Programmed cell death-1 (PD-1) immune checkpoint inhibitor antibody has proven to be effective in advanced non-small cell lung cancer (NSCLC) patients positive for programmed cell death-1 ligand-1 (PD-L1). However, there are currently no prospective studies evaluating PD-L1 expression for small biopsy samples. Methods To prospectively investigate the reliability of small samples for
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WhatsAppGet PriceGet A QuoteDesign Cell Lung For Crusher Capturing functional two-dimensional nanosheets 2021-2-18 Subsequently, the cells were broken by an ultrasound cell crusher and the content of GSH in the supernatant detected using a GSH assay kit.
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WhatsAppGet PriceGet A QuoteLung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. A systematic approach to initiating and characterizing cell lines from small cell and non–small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines, a number that exceeds those
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WhatsAppGet PriceGet A QuoteIn addition, even in the case of advanced-stage disease, accounting for 65% of non-small cell lung cancer (NSCLC) , adequate amounts of tissue specimens without crush artifacts are required, because identification of the tumor’s immunohistochemical and molecular characteristics is necessary for its appropriate management [7, 8].
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WhatsAppGet PriceGet A QuoteBackground/Aims: The diagnosis of small cell lung carcinoma (SCLC) on bronchial biopsy is often problematical as a result of intense crush artefact. Several antibodies are now available to help in the diagnosis of SCLC and their value was assessed in this clinical situation. Methods/Results: Twenty cases of SCLC and 10 control cases (one non-Hodgkin lymphoma, three non-small cell carcinomas
WhatsAppGet PriceGet A QuoteBackground Programmed cell death-1 (PD-1) immune checkpoint inhibitor antibody has proven to be effective in advanced non-small cell lung cancer (NSCLC) patients positive for programmed cell death-1 ligand-1 (PD-L1). However, there are currently no prospective studies evaluating PD-L1 expression for small biopsy samples. Methods To prospectively investigate the reliability of small samples for
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WhatsAppGet PriceGet A QuotePurpose: Previous genomic studies have identified two mutually exclusive molecular subtypes of large-cell neuroendocrine carcinoma (LCNEC): the RB1 mutated (mostly comutated with TP53 ) and the RB1 wild-type groups. We assessed whether these subtypes have a predictive value on chemotherapy outcome. Experimental Design: Clinical data and tumor specimens were retrospectively obtained from the
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WhatsAppGet PriceGet A QuoteSmall cell lung cancer is a highly aggressive malignancy. Currently, there is no effective regimen for patients after the progression offirst-line chemotherapy. The prognosis of patients with extensive disease is very poor, and the improved therapeutic efficacy is urgently needed. Most patients with small cell lung cancer have a long history of smoking, and the tumor mutation burden is
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WhatsAppGet PriceGet A QuoteAbstract: Background: The increasing cases of non-small cell lung cancer pose a relentless threat to human health. Therefore, using fragment-based drug discovery as the modus operandi, the present study aimed to design small molecule inhibitors for Anaplastic Lymphoma Kinase (ALK) positive Non-Small Cell Lung Cancer (NSCLC) and for its secondary mutation (F1174L).
WhatsAppGet PriceGet A QuoteDesign and synthesis of chitosan nanoparticles conjugated with folic acid for targeted transfer of miR-126 to lung cancer cell lines; Fooroogh Nikchehreh Golafzani, 1 Sepideh Khaleghi, 2,* Masoud Javanmardi, 3 1. department of medical biotechnology, faculty of advanced science and technology, Tehran medical science, Islamic Azad University, Tehran, Iran.
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WhatsAppGet PriceGet A QuoteLung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. A systematic approach to initiating and characterizing cell lines from small cell and non–small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines, a number that exceeds those
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